Human Cytomegalovirus Glycoprotein B Nucleoside-Modified mRNA Vaccine Elicits Antibody Responses with Greater Durability and Breadth than MF59-Adjuvanted gB Protein Immunization
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منابع مشابه
MF59-adjuvanted influenza vaccine (FLUAD®) elicits higher immune responses than a non-adjuvanted influenza vaccine (Fluzone®): A randomized, multicenter, Phase III pediatric trial in Mexico
The poor immune response elicited by trivalent influenza vaccines (TIVs) in children can be enhanced by the addition of adjuvants. This observer-blind, randomized Phase III trial assessed the immunogenicity and safety of the MF59-adjuvanted trivalent influenza vaccine FLUAD® (aTIV) and a non-adjuvanted TIV, in healthy children (aged 6 to <72 months) from 3 centers in Mexico, during the 2014-201...
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in Adolescent Girls David I. Bernstein, MD, MA; S. Todd Callahan; Flor Munoz-Rivas, MD; Rick Rupp, MD; Kathryn Edwards, MD, FIDSA; Lawrence R. Stanberry, MD, PhD; Sylvie Pichon; Cyrille Amegashie; Abbie R. Bellamy; Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH; Division of Adolescent and Young Adult Health, Vanderbilt, Nashville, TN; Baylor College of M...
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BACKGROUND Pathogenic avian influenza virus (H5N1) has the potential to cause a major global pandemic in humans. Safe and effective vaccines that induce immunologic memory and broad heterotypic response are needed. METHODS AND FINDINGS Healthy adults aged 18-60 and > 60 years (n = 313 and n = 173, respectively) were randomized (1:1) to receive two primary and one booster injection of 7.5 micr...
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Introduction: Glycoprotein B (gB) is the major antigen for induction of humoral responses against human cytomegalovirus (HCMV) making it an attractive candidate for immune prophylaxis. In the present study, the humoral immune response of BALB/c mice to a truncated HCMV gB protein fused with GFP was evaluated. Methods: The truncated gB coding sequence was synthesized and cloned in pEGFPN1 eukary...
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BACKGROUND Cytomegalovirus end-organ disease can be prevented by giving ganciclovir when viraemia is detected in allograft recipients. Values of viral load correlate with development of end-organ disease and are moderated by pre-existing natural immunity. Our aim was to determine whether vaccine-induced immunity could do likewise. METHODS We undertook a phase-2 randomised placebo controlled t...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2020
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00186-20